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Washington hospitals will face an unprecedented capacity crisis in January

[KIRKLAND, Wash.] – (MTN) The promises of the COVID Omicron variant being “very mild” and only a cold are crumbling in London and New York. The crush of COVID-related hospitalizations has United Kingdom officials considering additional restrictions while New York officials issued a warning about a shocking rise in pediatric hospitalizations. Hospitals in Washington are more than 90 percent occupied, leaving almost no capacity to deal with any kind of surge, COVID or otherwise.

Reports, studies, and data are pouring in at an incredible rate from around the world with confusing and conflicting headlines. In the United States, the politicization of the COVID epidemic has created a news cycle more aligned to opinion and speculation, than a cautious review and analysis of available data. If Washington follows the United Kingdom and New York, hospitals across the state will be overwhelmed by the end of January.

When Omicron was first announced by the World Health Organization on Nov. 26, many latched on to the words of Dr. Angelique Coetzee, chair of the South African Medical Association when she described the variant as “very mild.”

“Most of them are seeing very, very mild symptoms and none of them so far have admitted patients to surgeries. We have been able to treat these patients conservatively at home,” she said.

Within hours more details emerged that had many advising caution. Dr. Coetzee isn’t a hospitalist and runs a private practice in the South Africa capital of Pretoria. She based her statements on seeing 24 patients, mostly college students, and 50 percent were vaccinated.

The World Health Organization (WHO) addressed her statement in a press release on Nov. 28.

“There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants. Initial reported infections were among university students—younger individuals who tend to have more mild disease—but understanding the level of severity of the Omicron variant will take days to several weeks.”

A month has passed since the WHO announced Omicron was a Variant of Concern (VOC). Data from South Africa, the UK, and New York is providing critical information on what will happen next for other nations including the United States.

Malcontent News has analyzed multiple studies, COVID case rates, hospitalization information, and mortality data from South Africa, the United Kingdom, and New York City. Our conclusion is that without drastic action in the next seven to ten days, Washington hospitals will face an untenable crisis by the end of January.

Researchers at the London School of Hygiene & Tropical Medicine (LSHTM) estimated Omicron was doubling every 2.4 days in the UK and has an Rt or “R naught” of 4.4. Rt is a measure of how quickly a disease can spread. At 3.0, up to 50 percent of people can expect to become infected with the Omicron variant – at 4.0, the figure jumps to 90 percent.

On Dec. 23, Trevor Bedford, Ph.D. with Fred Hutch, estimated that Omicron was doubling every 2.4 days and had an Rt of 4.4 in King County.

Case information from South Africa’s hospitals has revealed that recent previous COVID Delta variant infections are not providing much protection from the Omicron variant. As hospitals in Gauteng Province became filled with COVID patients, reaching a peak days before Christmas, a pattern emerged. Over 80 percent were unvaccinated, and in the ICU, almost all the patients were unvaccinated.

Mortality rates in South Africa remained low through Dec. 10 and then started to climb. On Sunday, 66 were dying of COVID daily based on the 7 day moving average, 87 percent are unvaccinated and 466 total deaths have been recorded in the last week.

While it is factually correct that only 26 percent of all South Africans are vaccinated against COVID, in Gauteng the numbers more closely mirror some Eastern Washington counties. On Dec. 17 South African officials reported 44% of all eligible adults in Gauteng are fully vaccinated, including 66% of people over 50 years old. Even at 26 percent, Stevens County is only 33 percent vaccinated and already experiencing high transmission.

South African officials found that although the risk of hospitalization from Omicron was as much as 70% lower than Delta, once a person was hospitalized, the disease progression resembled Delta with similar patient outcomes. Scientists in Europe and North America worried that the younger, relatively healthy population was masking the true impact of Omicron. Hospitals also saw a surge of children under five being hospitalized.

Washington and King County have far fewer children under 18 and a much older population than South Africa. The single biggest factor that determines the outcome of a COVID infection is age, even among the vaccinated. Multiple studies have concluded that without a booster shot, neutralizing antibodies against COVID has faded away, leaving the T cells to respond in a secondary response. Boosters dramatically improve the body’s response to Omicron, but less than half of eligible residents of King County have been boosted.

In a damaging blow to reaching a better understanding of the Omicron variant, the South Africa Department of Health announced on Dec. 24 the nation would stop most contact tracing, reduce quarantine times for infected people, and significantly reduce COVID testing. Reducing the number of tests will lower the daily case count while inflating the percentage of hospitalization patients. Shortening of quarantine periods for positive tests while ending most contact tracing could drive a new surge of community transmission.

As Omicron started to spread around the world, the National Health Service (NHS) in the UK reported 131 Omicron variant cases on Dec. 8. The first Omicron variant death was reported on Dec. 14 and by Christmas Eve, the NHS reported 122,186 cases as hospitalizations started to surge.

Bedford predicted on Dec. 18 that King County would have 2,100 new COVID cases by Dec. 23, which would shatter previous records. King County Public Health reported 2,879 new cases, a 169 percent increase in a week. Hospitalizations are a trailing indicator and looking at London and the UK, an increase in King County is roughly a week away.

Today, UK COVID hospitalizations are doubling every ten days. For the unvaccinated, people from 50 to 79 have a 30-fold greater chance of being hospitalized. The Intensive Care National Audit and Research Centre examined hospitalization data from May to November and found that the unvaccinated had a relative risk to be hospitalized 60-times higher than the vaccinated – that data was without boosters.

According to the most recent data available, the UK National Health Service reported 1,171 people were admitted to hospitals with COVID on Dec. 20 – the highest number since Feb. 19 and higher than during the Delta wave. On Dec. 22, the 7-day moving average for new hospitalizations in London had reached 386, just a handful of cases below a “trigger number” of 400. The figure is half of the previous record peak of 850. If cases double again in the next ten days, a new and awful record would be in reach.

The LSHTM released an updated pre-print study on Dec. 23 modeling four potential scenarios for the UK and the progression of Omicron. The report was adjusted to factor in newly available data from the Imperial College of London published on Dec. 22. Report 50 hypothesized previous Delta infections combined with high vaccination rates in the UK would reduce the risk of hospitalization from an Omicron infection by 50 percent.

“These results suggest that the introduction of the Omicron B.1.1.529 variant in England will lead to a substantial increase in SARS-CoV-2 transmission, which, in the absence of strict control measures, has the potential for substantially higher case rates than those recorded during the Alpha B.1.1.7 winter wave in 2020–2021. This is due to Omicron’s apparent high transmissibility and ability to infect individuals with existing immunity to SARS-CoV-2 from prior infection or from vaccination.”

Only one scenario found that hospitalizations would be below the record the UK set in January 2020. The most likely scenario of high immune escape with high booster dose efficacy predicts hospitalizations could soar to 5,000 a day by the end of January 2021. The National Health Service would have no capability to care for that many patients, even if they only required a few days of care with hydration and oxygen support.

The study also found that this was not inevitable, and additional mitigation plans to slow the spread of COVID could protect the hospital system and UK residents alike. However, the steps required are very unlikely to be taken or tolerated.

“The introduction of control measures is projected to partially suppress Omicron transmission; however, in the most pessimistic scenario, we project that stringent control measures such as those implemented following the Alpha B.1.1.7 winter wave of transmission may be required to ensure that healthcare services are not overwhelmed.”

In the United States, federal officials have openly stated concern that restrictions such as those used in the spring of 2020 could bring a wave of domestic terrorism. On Nov. 11, the National Terrorism Advisory System Bulletin stated, “Pandemic-related stressors have contributed to increased societal strains and tensions, driving several plots by DVEs, and they may contribute to more violence this and next year. If a new COVID-19 variant emerges and new public health restrictions are imposed as a result, anti-government violent extremists could potentially use the new restrictions as a rationale to target government or public health officials or facilities.”

In King County, there are very few remaining public health options. The county has had a mask mandate in place since July with varying levels of compliance. Proof of vaccination or a negative COVID test is required to go to restaurants, bars, theaters, sports events, movies, gyms, and entertainment venues. However, one doesn’t have to dig deep to find Facebook groups and online lists of hundreds of businesses ignoring these requirements.

On the other side of the country, New York City is seven to ten days ahead of Seattle. Tens of thousands of, “guess who has COVID,” social media posts morphed into, “this is much worse than I thought” updates over the Christmas holiday. The number of hospitalized COVID patients almost doubled in a week in the City – from 1,046 on Dec. 18 to 1,904 on Dec. 24. The number of coronavirus patients in the ICU went from 187 to 283 during the same period. On Christmas Eve, parts of Manhattan had the highest COVID transmission rates on the planet.

New York Health Commissioner Mary T. Bassett issued a statement on Christmas Day, with pediatric COVID hospitalizations quadrupling in three weeks. “We are alerting New Yorkers to this recent striking increase in pediatric COVID-19 admissions so that pediatricians, parents, and guardians can take urgent action to protect our youngest New Yorkers.”

Officials did not release a patient census but did offer some information. Half of the hospitalized children were under five. None of the children under 12 were vaccinated, and only one-third of adolescent patients from 12 to 17 were fully vaccinated. Booster shots are not available to children under 16, and only recently became available to 16 and 17-year-olds.

The Washington Post reported that pediatric hospitalizations for COVID had jumped 31 percent in ten days, with almost 2,000 children hospitalized – a grim and new national record.

Pediatrician Aaron Milstone with Johns Hopkins University School of Medicine urged parents who have children with “cold” symptoms to assume “it’s Omicron until proven otherwise,” in an interview with the Washington Post.

Unlike South Africa and the United Kingdom which released updated reports over the Christmas holiday, data hasn’t been available from the Washington State Depart of Health (WSDoH) since Thursday. With new cases doubling every 2.4 days in King County, it is almost certain Washingtonians will see a dramatic increase in new COVID cases and COVID hospitalization in the coming week.

When it comes to the state’s ability to cope with another surge, Washington State Hospital Association (WSHA) Vice President Taya Briley minced no words during a Dec. 23 press briefing.

“Even if most people don’t get really sick, there are a lot of people who are getting infected with omicron, and some portion of them will get severely ill and need hospital care. Even if it’s a small portion of the overall total, this could mean a huge number of people getting sick enough to need hospitalization.”

Mark Taylor of the Washington Medical Coordination Center at Harborview Medical Center in Seattle, echoed her perspective.

“We really do not currently have the capacity within our facilities to accommodate a large surge as we just came through with the Delta surge.”

The most recent data available from the WSDoH is from Dec. 22. On Wednesday, there were 702 COVID patients hospitalized in Washington, with 95 requiring ventilators. The number of hospitalized patients had increased 13 percent in 48 hours before the Christmas holiday data break.

Using the 7 day moving average data from the Healthcare Readiness tab from the WSDoH COVID dashboard, there are an estimated 652 staffed acute care and 145 staffed ICU beds available across the state. If COVID cases were to double over the next ten days regional hospitals will run out of all beds, unless other measures are taken.

Demoralized doctors and nurses are already in a physical, emotional, and mental health crisis as the Delta wave was coming to an end. Over the weekend, many expressed fury at new guidelines released by the Centers for Disease Control (CDC) on Christmas Eve.

The new guidelines reduced the amount of time medical personnel needs to isolate if they have close contact or are positive for COVID. If hospitals move to contingency care hospital workers could be made to return to work after five days, even if they are mildly symptomatic. Under crisis standards of care, employees could be made to continue to work even if they are experiencing mild or moderate symptoms.

The CDC defines moderate illness as, “individuals who have evidence of lower respiratory disease, by clinical assessment or imaging, and a saturation of oxygen (SpO2) ≥94% on room air at sea level.”

More troubling, The update has no specific requirements for N95 masks or N100 respirators, defining facemasks as, “OSHA defines facemasks as “a surgical, medical procedure, dental, or isolation mask that is FDA-cleared, authorized by an FDA EUA, or offered or distributed as described in an FDA enforcement policy. Facemasks may also be referred to as ‘medical procedure masks’.”

The medical community is concerned that COVID could be passed to patients hospitalized for other reasons, while spreading among other staff, limiting the ability to meet rising cases. In states where medical personnel isn’t required to be vaccinated, data from South Africa and the UK suggests the CDC guidelines could have a devastating impact on hospital readiness.

As a better understanding of Omicron has become available a grim picture for January is emerging. In King County, 81.3% of all residents five and older are fully vaccinated. That is almost ten percent lower than London and the vaccination rate for Washington state isn’t much higher than Florida.

Several studies have shown that the current vaccines from Moderna and Pfizer have significantly reduced effectiveness without a booster. The Johnson & Johnson vaccine is even less effective. Boosters have been proven to provide additional projection, but breakthrough cases remain frequent. For most of the vaccinated that develop symptoms, their cases are mild to moderate.

The number of breakthrough cases had driven up anti-vaccination rhetoric at a national and even local level, with Jason Rantz criticizing the King County vaccine mandate.

“But if Omicron evades the vaccine and the best protection, according to the city, and the department is to abide by procedures used before a vaccine was even available, then what sense did it make to fire unvaccinated staff? They’re just as vulnerable to the dominant variant as the vaccinated.”

The statement is factually incorrect, given the evidence from South Africa, Israel, Denmark, and the UK showing that while breakthrough cases among the vaccinated are high, hospitalizations are extremely low.

Several case studies on the true number of breakthrough cases and vaccine effectiveness have emerged in an unlikely place. Multiple cruise ships have had their itineraries disrupted due to onboard COVID cases. The Royal Caribbean ship, Odyssey of the Seas, was denied entry to two ports of call after confirming 55 coronavirus cases onboard. The ship left port with 95 percent of passengers fully vaccinated. The ship has 3,587 guests and 1,599 crew onboard. If every confirmed case was among vaccinated individuals, the breakthrough rate is around one percent. Officials have stated the cases are asymptomatic or mild.

The new case rate in King County is growing as fast as London with a similar Rt, which indicates up to 90 percent of residents will become infected with COVID in the next 60 days. Most of those cases will be asymptomatic or mild, but for the elderly, children under five years old, the unvaccinated, and the immunocompromised the data strongly suggests outcomes are similar to Delta.

Considering all we have learned about Omicron since Nov. 27 and looking at the data through a clinical, not-politically motivated lens, an unprecedented crisis will arrive with the New Year. If cases continue to double every 2.4 days and the Rt stays above 4, up to 90% of King County residents will be infected over the next 60 days. If COVID hospitalizations double every ten days starting this week, the state will be out of resources by Jan. 15.

As the Omicron variant spreads through Eastern Washington, likely fueled by Christmas holiday travel, officials will look to Western Washington to take their patients. The issues experienced during the Delta surge of patient transfers by aircraft and ambulance will be even worse due to winter weather and an increasing number of sickened personnel.

With pandemic fatigue, politicization, Christmas and New Year’s travel and celebration, and no ability to add additional public health measures without risking a violent response, it seems unlikely that we will prevent what is coming.

Washington watches and waits for the Omicron COVID variant to arrive

Knowledge is the best tool to fight against fear. A wise person chooses to be informed so they can make sound decisions. To join the fight against COVID misinformation, you can share this update through your social media platform of choice.

[KIRKLAND, Wash.] – (MTN) Health officials and researchers are in a race against time to unlock the secrets of the Omicron COVID variant and its potential impact on public health as more nations report discovered cases.

Washington state is one of the leaders in genomic sequencing of COVID tests samples in the United States, led by the University of Washington Medicine. Standard PCR tests can detect a marker for a potential Omicron variant. Omicron shares a mutation with the Alpha variant that the current PCR tests look for, enabling researchers to see if a specific spike protein has a deletion. That would become a probable case that would be tagged for confirmational sequencing.

President Joe Biden addressed the nation on Monday saying, “there are three messages about the new variant that I want the American people to hear. First, this variant is a cause for concern, not a cause for panic.”

The President went on to praise South African officials and their scientific community for, “the kind of transparency that should be encouraged and applauded.”

Currently, in Washington, 99.6% of new COVID cases are the Delta variant, and 0.4% are Mu. The last cases of the Beta, Epsilon, Eta, and Kappa variants were detected in June and the last cases of Gamma and Iota were in August.

“Omicron has an unprecedented number of spike mutations, some of which are concerning for their potential impact on the trajectory of the pandemic,” the WHO said in a statement today.

“The overall global risk related to the new variant …is assessed as very high.”

On Sunday, Dr. Angelique Coetzee told South Africa Today, “Most of these cases are mild whether they are vaccinated or not. There is no increase in our hospital admissions currently.”

Hospital admission for COVID-19 by week, South Africa Gauteng Province, Public and Private Hopsital, through November 28, 2021

Less than 12 hours later, the hospital admission data from the South Africa Department of Health painted a very different picture. In the previous week, COVID hospitalizations had increased 66% nationwide and 210% in Gauteng Province, the epicenter for Omicron cases. Two weeks ago 135 Covid-19 patients were hospitalized in and around Johannesburg jumping to 580 on Monday morning. Hospitalizations at public and private hospitals increased almost equally and officials at Baragwanath Hospital reported moderate to severe symptoms with almost all patients unvaccinated or partially vaccinated with the Pfizer vaccine.

Dr. Coetzee in her interview on Sunday went on to take a more cautionary position, “Two weeks from now we might say something different, but we urge…people out there please get vaccinated, listen, do the right thing, and stop going to big gatherings.”

She also added the unvaccinated should be worried, saying, “especially if you are above the age of 50, we have seen this many times.”

“There is a saying. You’re not safe until everyone is vaccinated.”

The 7 day rolling average for new COVID cases in South Africa grew to 2,275 on Monday, 90% of new cases are Omicron, and 10.8% of tests are coming back positive

The WHO appeared to address the reports from Dr. Coutzee and her reports on the severity of the new variant in a statement last night. “There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants.”

The statement added, “Initial reported infections were among university students—younger individuals who tend to have more mild disease—but understanding the level of severity of the Omicron variant will take days to several weeks.”

Dr. Coetzee saw her first suspected Omicron variant patient on November 18 and has based her statement of symptoms being mild on two-dozen patients who are mostly university students and younger, and about 50% vaccinated. In an interview with the BBC on Thursday, she stated all were in good health with no comorbidities.

Although she is credited and has self-proclaimed to have “discovered” Omicron, the first detection of the B.1.1.529 variant was collected on November 9 in Botswana and confirmed by South African scientists on November 11. South African officials notified WHO on November 24, a day before Dr. Coutzee stated she contacted South African authorities on her observations.

Despite a lot of unanswered questions, a clearer picture is slowly starting to emerge. The three riddles scientists need to solve are how contagious Omicron is compared to the Delta variant, can it escape public health measures, preventions, and treatments, and if the symptoms are the same, worse, or milder than previous variants.

Here is what is currently known about the Omicron COVID variant.

Symptoms

For children, adolescents, and young adults there is conflicting information. One doctor is reporting mostly mild symptoms that can be treated at home while hospital officials are reporting cases are similar to Delta.

The WHO stated on Sunday, “There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants.”

Transmissiblity

Concern is growing among the CDC, WHO, and a constellation of health officials that Omicron is highly transmissible. At least equal to Delta and possibly higher.

In less than two weeks, Omicron went from almost non-existent to 90% of new cases in South Africa. It appears it can effectively outcompete the Delta variant. However, this introduces bias in the data because the Delta wave had just ended in South Africa. Did Omicron become the dominant strain by outcompeting Delta or due to the absence of Delta? More research needs to be done to answer that question.

There are other variables that could explain the sharp increase in cases that go beyond the simple reproductive number, known as R0. Omicron has so many more mutations than previous strains, it could be benefiting from immune escape. Although the R0 is lower than Delta, its uniqueness compared to previous mutations enables it to reinfect people relying on natural immunity. So overall transmissibility may be lower than Delta, but its ability to escape immunity results in more infections.

Is it in the United States

Cassie Sauer, CEO of the Washington State Hospital Association said on Monday, “I think that there is almost no chance that it’s not [here.]”

The United States does not have a national standard or requirement to genetically sequence some or all COVID tests that come back positive. Those decisions are left up to individual states. It is likely that states with aggressive public health programs such as California, Washington, Colorado, New York, or Massachusetts will identify the first cases.

How long do researchers think Omicron has been circulating

Dr. Trevor Bedford from Fred Hutchinson in Houston, Texas successfully estimated the arrival of the original COVID strain in 2020, using data from the Washington State Department of Health. Using the same methodology, Dr. Bedford’s model indicates that Omicron likely started circulating between September 19 and October 21. There is no evidence to support that the variant originated in South Africa.

Credit – Dr. Trevor Bedford, Fred Hutchinson, Houston, Texas – probability of origin date for Omicron variant

Why are so many travelers testing positive

In total numbers, there aren’t many travelers testing positive. When you consider that in all but two cases the testing of 200 to 250 people on an aircraft has yielded one or two positives, the percentage of breakthrough cases is small. Headlines are blaring two positive cases detected, which is critical to know – they aren’t blaring 248 negative tests on 777 that landed tonight.

Because the people tested are 95% to 100% vaccinated, this creates a false data fallacy. You have an almost exclusive sample of vaccinated people.

In South Africa, the Department of Health has reported almost everyone hospitalized in the last two weeks is unvaccinated or only partially vaccinated. Dr. Coetzee reported 12 of 24 patients she cared for were unvaccinated.

Based on this early data, it appears the current vaccines remain at least moderately effective at preventing infection and remain very effective at stopping moderate to severe COVID.

Are the current vaccines ineffective

There isn’t enough data, and almost every public company making a vaccine announced over the weekend they were testing their current versions against Omicron. Pfizer, Moderna, and Johnson & Johnson announced over the holiday weekend they were testing to see if the current vaccines remained effective.

There is some data out of South Africa that is indicating that vaccines are helping prevent moderate to severe illness and the cases being detected among vaccinated travelers appear to be asymptomatic to mild. However, many of those cases were detected in the last 72 hours and more time is needed to see how these new cases will progress.

In Israel, the first three travel-related cases were fully vaccinated with boosters. One was Pfizer, one was J&J, and one was AstraZeneca. We know that the viral-vector vaccines haven’t performed as well against the Delta variant as the mRNA vaccines.

The evidence suggests that there is more vaccine escape with Omicron, but not outright vaccine ineffectiveness. It still appears to be preventing hospitalizations, which would indicate it would prevent deaths.

Pfizer said they could make a new version if required in 100 days and Moderna said it would take 60 to 90 days. Johnson & Johnson did not provide a timeline but made a statement today they could create an updated version if it was required.

There are some new COVID vaccines in development called subunit vaccinations. There has been no information about the impact Omicron will have on the research.

Is disease acquired immunity still effective

There is growing evidence that immunity gained from a previous COVID infection that isn’t supported by vaccination, is experiencing significant breakthrough numbers.

Researchers are working to determine if the sharp increase in the number of cases and the high positivity rate of tests is due to Omicron being equally or more transmissible than Delta, or if part of the increase is being driven by other factors.

The pattern of mutations found in Omicron is very distant from all previous strains.

Are monoclonal antibodies still effective

There is evidence that Omicron has a significant ability to resist monoclonal antibodies. Specific mutations may have the capability to not only bypass B cells but resist T cells (which isn’t the same as HIV which destroys your T cells).

UW Medicine is evaluating the performance of currently available antiviral treatments and we will know more information in the coming weeks.

Will the new antivirals that are pending approval still be effective

There was a report from Pfizer on Monday morning that Paxlovid is effective against the Omicron variant, which is very good news. This is easy to administer than monoclonal antibodies, easier to distribute, and cheaper.

Nothing has been stated about Monulpiravir from Merck. The FDA will be considering the EUA request this week but there are hints they will label Monulpiravir a Class C drug if the EUA is granted. A Class C drug can’t be used by pregnant women, women actively trying to get pregnant, and nursing mothers because the drug has not been tested to determine if it causes birth defects or pregnancy complications. The FDA has already requested data for Merck to understand the impact better.

What should I do

Health officials recommend you continue to do the same things you are doing now. Get vaccinated if you’re not already. Get a booster shot if you’re eligible, and over 2.4 million Washingtonians are currently eligible. Wear a mask, wash your hands, avoid crowded indoor spaces, and reconsider your short term travel plans if you were planning to fly.

WHO holds emergency meeting as multiple nations implement Africa travel restrictions over new COVID variant concerns

[KIRKLAND, Wash.] – (MTN) World health officials are alarmed due to a new fast-spreading Covid-19 variant in South Africa causing the World Health Organization to hold an emergency meeting as Asian stock markets plunged and the Dow Jones futures dropped 735 points.

The new variant, so far identified as B.1.1.529 has not been named, but the WHO is expected to assign it a name today, likely the Nu variant.

The variant was first detected in Botswana but has quickly spread in South Africa and two travel-related cases have been confirmed in Hong Kong. Botswana officials stated the four detected cases are among fully vaccinated individuals. in South Africa, cases are increasing rapidly in Gauteng Province, home to Johannesburg and one of the largest air travel hubs on the continent. In the span of a week, new cases went from a cluster to growing so fast scientists believe it has achieved community spread.

Officials in the U.K. are taking no chances. Health Secretary Sajid Javid announced that six African nations – South Africa, Namibia, Zimbabwe, Botswana, Lesotho, and Eswatini – have been placed on the red list, placing strict rules on air travel.

Starting on Friday, any non-UK and Irish residents will be banned from entering England if they have been in the red list countries in the last ten days. Beginning Sunday, British nationals who have been in those countries will be required to quarantine upon entry. Additionally, health officials in the UK are asking anyone who has traveled to the impacted regions to get a PCR test as soon as possible.

South Africa’s Foreign Minister Naledi Pandor said the travel restrictions “seems to have been rushed,” in a statement where he expressed concern over the impact on tourism and business.

Israel and Singapore joined the U.K. early on Friday and added Mozambique to their travel restriction lists.

New case rate growth is much faster than Delta, which indicates the potential for a very high R0, or “r-naught,” which is the measure of how transmissible a communicable disease is. In little more than two weeks, B.1.1.529 has grown to almost 90% of all detected cases in South Africa.

According to Johns Hopkins University, only 24.11% of South Africans are fully vaccinated which would aid a new variant to spread unchecked. Health officials in South Africa and with the WHO are concerned that the new variant is circulating more widely than current data suggests.

The B.1.1.529 has more than 50 mutations, which is significantly higher than any other viable variant previously seen. More than 30 of those alternations are changes to the spike protein, which is the mechanism that enables the SARS-CoV-2 virus to identify hosts cell and is the primary target of the body’s immune response.

B.1.1.529 has more than twice the number of mutations as the Delta variant

In a report published by the Journal Nature, Penny Moore, a virologist at the University of Witwatersrand in Johannesburg, indicated that computer models suggest not only does B.1.1.529 have mutations that are already known to aid in evading an immune response from B cells but could fool the body’s T cells.

B cells do the yeoman’s work of fighting virus infections, but have a shorter memory and can be tricked by a smaller set of mutations. T cells are the second line of immune defense with better memory and capabilities to spot mutations. When T cells identify a threat that was initially missed, they summon B cells to aid in the response. This is how disease acquired and vaccine immune response works. If the new variant is capable of evading T cells then the benefits of vaccine immunity would be reduced and disease acquired immunity could be rendered ineffective.

Disease acquired and vaccine immunity works the same. Antibodies bind to the spike proteins preventing the virus from entering cells so it can replicate. If the antibodies can’t bind to spike mutations and the mutations still enable the SARS-CoV-2 virus to identify host cells, the virus can spread inside the body unchecked causing a Covid-19 infection.

Another challenge is if these findings are accurate – the new variant may be capable of outmaneuvering monoclonal antibodies – blunting a critical early treatment.

One mutation is helping scientists track the spread of the new variant. A specific mutation to the spike protein enables researchers to identify the variant through a standard PCR test instead of waiting for genomic sequencing.

Currently, there are more questions than answers. Researchers know the new variant is spreading rapidly in South Africa and causing a new surge. What is not known is if the rapid spread is being driven by a mostly unvaccinated population or because it is more transmissible. It also is not known if the new variant causes equal, more severe, or mild illness. There is no data about the capability the new antivirals Molnupiravir and Paxlovid could have in fighting B.1.1.529.

It is important to note that Beta, Gamma, and Mu were previous variants found to have high resistance to vaccine and disease acquired immunity but weren’t very transmissible. All three variants faded out because Delta was more contagious. In the simplest terms, Delta outbred the other variants. A key requirement for a new variant to spread rapidly would be the capability to outrun Delta.

Most important of all, there is no concrete scientific evidence that B1.1.529 is evading viral vector or mRNA-based vaccines. Previous variants have taken months to identify while this one was found, sequenced, and placed under investigation in a matter of days.

No cases have been detected in North America or any United States territories.