[OLYMPIA, Wash.] – (MTN) The Washington State Department of Health (WSDoH), in partnership with the UW Medicine Virology Laboratory, has confirmed a total of three cases of omicron variant in Thurston County, Pierce County, and King County. The patients range in age from 20 to 39, two men, one woman.
The patients are:
a man in his thirties from Thurston County,
a man in his twenties from Pierce County, and
a woman in her twenties from King County.
Confirmation came in midday Saturday, and officials were still in the process of notifying the patients.
The WSDoH did not have information on their condition, travel history, or vaccination status. The samples were collected using PCR tests between Nov. 29 and Dec. 1 and were submitted for genomic sequencing.
Sequencing has been prioritized for anyone with travel history or close contact with a confirmed case.
“We knew that it was a matter of time before omicron was sequenced in our state and so we were anticipating this very news,” said Umair A. Shah, MD, MPH, Secretary of Health. “We strongly urge people to get vaccinated and get their boosters as soon as possible to maximize their level of protection from any variant.”
“Even with a highly mutated virus-like omicron, we are not going back to square one of the pandemic,” said Dr. Jeff Duchin, Health Officer, Public Health – Seattle & King County. “Omicron may pose new challenges that we will need to respond to, but compared to the early days of the pandemic, we know much more about COVID-19, and we’re better prepared for it. We know layered protections work together to maximally reduce risk, and that will continue to be the case for delta and for omicron if that becomes a dominant strain circulating in our community.”
“We suspected that the omicron variant was circulating in our region, and now our laboratory has confirmed the first three cases in Washington state by viral genome sequencing in the last 24 hours. Throughout the pandemic, it’s been a huge team effort by the UW Medicine Virology Laboratory, requiring development and implementation of several diagnostic and sequencing assays to detect and confirm the variety of COVID-19 variants that have surfaced in Washington state,” said Dr. Geoffrey Baird, chair of Laboratory Medicine and Pathology at UW School of Medicine. To date, the laboratory has tested approximately 3.8 million COVID-19 samples.
A study about the transmissibility of the omicron variant was released from a multinational group of researchers on Friday. The study, which has not been peer-reviewed, indicated that omicron is two times to three times more transmissible than the prevalent delta variant. Researchers estimate that the Rt, called, “r-naught,” is R12 to R17, which is equivalent to measles. The Rt for delta is R6.0 and for the AY.4.2 delta variant is R6.6.
Another study released on Thursday indicated that people relying on disease acquired immunity are up to 240% more likely to be infected from the omicron variant versus the beta or delta variants.
The CEOs of Pfizer and Moderna stated their vaccines would remain highly effective at preventing severe COVID and hospitalizations. Researchers are still one to two weeks away from preliminary information on if there will be significant vaccine escape with the omicron variant.
Public health officials are recommended for the unvaccinated to get vaccinated and for the 2.2 million Washingtonians eligible for a booster to get one. Washington state continues to have an indoor mask mandate.
Individuals who are experiencing COVID-like symptoms or have a known close contact should get tested. If you have traveled or know you had close contact with a traveler and get a positive test result from a home test, you should follow up with a PCR test to aid in tracking the spread of the omicron COVID variant.
Knowledge is the best tool to fight against fear. A wise person chooses to be informed so they can make sound decisions. To join the fight against COVID misinformation, you can share this update through your social media platform of choice.
[KING COUNTY, Wash.] – (MTN) Officials in five states have reported Omicron cases from Hawaii to New York, as the world races to better understand the danger the new variant presents.
In Washington, the first set of local COVID data was made available in a week, indicating that hospitalizations are plateaued again and new cases are down. Twenty-six counties no longer have high rates of transmission. There was an increase in new cases among 20 to 49-year-olds compared to last week.
Governor Jay Inslee reported that FEMA was sending two mobile vaccination clinics to King County, with the first one opening on December 20 in Federal Way.
One-third of the 3.3 million booster eligible residents of Washington have leveled up, while in some areas people are searching for appointments to get a third dose.
Almost 75% of residents age 12 and over are now fully vaccinated, and 17% of all Washington children ages 5 to 11 have received at least one dose of the Pfizer vaccine.
Locally, new COVID cases in the Bellevue, Lake Washington, and Northshore School Districts were down from last week. Vaccination rates for children 5 to 11 that live in the three districts are remarkable with some zip codes reporting almost 60% of all kids already receiving their first dose.
In national news, the United States has confirmed ten Omicron variant cases in California, Colorado, Hawaii, Minnesota, and New York. The infections in Hawaii, Minnesota, and several in New York were caused by community transmission.
President Joe Biden announced new programs to try and combat the spread of COVID in the United States, but Republicans in the Senate threatened to have the United States default on the national debt if he implemented meaningful strict measures.
In South Africa officials are becoming increasingly alarmed as new cases and hospitalizations increase exponentially. The Gauteng Province, home to 15.7 million is the hardest hit, but cases were increasing across the nation. Officials there reported COVID hospitalizations increased more than 23% overnight, and ICU admissions jumped almost 40%.
A study published tonight from South Africa reported that people relying on natural immunity had a 240% higher chance of reinfection with the Omicron variant, compared to the Beta or Delta variants.
In disinformation, we explore the claim that the Omicron variant is no worse than a cold or flu.
No promotional consideration has been given, or requested from the n95 project or any manufacturer of masks
Washington State Update for December 2, 2021
Washington state Covid-19 update
After a six-day break from updated and accurate data from the Washington State Department of Health, we’re back. A week ago the question was how much would Thanksgiving travel impact new case rates. The Omicron variant has changed the plot.
Vaccination data for the state was updated. A couple of counties had numbers drop from last week. This has happened before as data gets validated but this update dropped Grant County below 50% – so the brackets changed.
Skagit and Whatcom Counties new cases rates are down about 40% from three weeks ago. The surge of cases among mostly unvaccinated residents is winding down. New
New cases have decreased a smidge compared to last week but do not reveal any significant trends.
Percent of Total Population Fully Vaccinated
Total Population in Group
Average 14-Day New Case Rate
70.00% or above (3 counties)
2,343,250
127.7
60.00% to 69.99% (5 counties)
1,374,000
261.0
50.00% to 59.99% (15 counties)
3,420,400
227.8
40.00% to 49.99% (9 counties)
487,375
234.7
32.30% to 39.99% (6 counties)
151,850
176.7
14-Day New Covid-19 Cases per 100K average by Vaccination Rate for Total Population, Adjusted for Population by County
Through December 2, Washington’s statewide 14-day rolling average is 203.2 Covid-19 cases per 100K, and the 7 day rolling average is 82.7.
No counties have a case rate over 400.0. per 100,000 residents. Twenty-six counties representing 5.65 million Washingtonians have a 7 day moving average case rate under 100.
New cases by age declined for every age group except 20 to 49-year-olds, which increased. Hospitalizations for ages 20 to 34 also increased.
Age Group
7-Day Case Rate
7-Day Hospitalization Rate
Ages 0-11
91.5
0.1
Ages 12-19
83.3
0.5
Ages 20-34
100.1
9.1
Ages 35-49
100.1 (not a typo)
5.5
Ages 50-64
73.8
8.8
Ages 65-79
44.1
10.2
Ages 80+
40.6
17.0
7-day case rate and 7-day hospitalization rate is per 100K within the age group – the target for 7-day case rate is <25.0, but there are other factors such as vaccination rates within the age groups, how many total tests within the 7-day period, and the positivity rate within each age group
The USA Today COVID Tracker has not been updated since November 30 but reports 9,303 Washingtonians have died from Covid-19 related illness.
FEMA sending mobile vaccination clinics to Washington
Governor Jay Inslee announced that FEMA would be sending two mobile vaccination clinics to Washington. The first site will open on December 20 in Federal Way and is slated to operate for a month. A second location is planned but a date and location were not announced.
“This is great news in the ongoing fight against COVID. I am grateful for our strong partnership with the federal government, and these FEMA Family Mobilization Clinics coming to King County is a great result of that partnership,” said Inslee. “This is an innovative model that will help increase equitable access to vaccination for all Washingtonians.”
A constellation of partners is working with FEMA including the Washington State Department of Health, the King County Executive’s Office, and Seattle & King County Public Health.
Some people in Western Washington have reported problems in securing vaccination appointments for boosters due to high demand.
One-third of booster eligible Washingtonians have leveled up
The Washington State Department of Health reported 1.08 million of the 3.3 million eligible for boosters have rolled up their sleeves. There is significant evidence that vaccine and disease acquired immunity declines after five to seven months, but a number of factors such as age and other health issues can affect the duration.
There is some evidence within the genetic sequencing of the Omicron variant that disease-acquired immunity from previous mutations won’t be as strong as vaccine-based immunity.
Over 17% of Washington kids age 5 to 11 have received their first dose of the COVID vax
The Washington State Department of Health reported 116,121 children from 5 to 11 have received their first dose of the Pfizer COVID vaccine, about 17% of all eligible kids in Washington.
The Pfizer vaccine Emergency Use Authorization (EUA) was amended to include 5 to 11-year-olds. They receive two smaller doses and reach fully vaccinated after five weeks. Initial data indicates that due to the stronger immune response of children and adolescents, a booster or third dose is not needed. That could change with time or if another variant emerges that is vaccine-resistant.
Washington state approaching 75% of population 12 and older fully vaccinated
The Washington State Department of Health reported 80.8% of all Washingtonians 12 and older have received at least one dose of the COVID vaccine and 74.6% are fully vaccinated.
Although this is good news, Washington is starting to fall behind other states. The Mayo Clinic reported that Washington was in 10th place for 12 to 17-year-olds fully vaccinated, 9th place for 18 to 64-year-olds, and tied with 32 other states for first place for 65 and older.
Travel Advisories
Due to the confirmation of community transmission of the Omicron variant in the United States, we are advising our readers to reconsider air travel and recreational travel plans. Especially if those plans include going to places with large crowds or major events at enclosed buildings.
Thank you
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King County, Washington is reporting over 85.0% of age eligible residents are vaccinated with at least one dose. The highest rates of positivity are in areas with low vaccination rates statewide. The FDA has provided full approval of the Pfizer vaccine for anyone 16 and over and EUA approval for the Moderna and Johnson & Johnson vaccines. The Pfizer vaccine has EUA approval for children 5 to 15 years old.
COVID vaccines and boosters are free for anyone 5 and older. Lyft and Hopelink provide free transportation, and KinderCare, the Learning Care Group, and the YMCA offer free childcare during vaccination appointments or recuperation.
It has been a week since the last report and hospital status has improved significantly while the number of COVID patients receiving care remains elevated. The Washington State Department of Health reported 89.4% of staffed acute care beds were occupied with 10.2% of patients infected with Covid-19. There are 706 COVID patients statewide with an estimated 212 in the ICU – 114 requiring ventilators.
Statewide, there are an estimated 753 acute care and 151ICU beds available.
On Wednesday, the 7 day rolling average hospital admission rate for new COVID patients was statistically the same as last week – 65.
Hospital status by region – ICU Occupancy should be below 80%, ICU COVID Patients should be below 20%, Acute Care Occupancy should be below 80%, and Acute Care COVID Patients should be below 10%
– Blackwell (1*/4) – Dickinson/Explorer (2*/7) – Eastlake High (1*/3) – Ella Baker (1*/0) – Evergreen Middle School (1*/0) – Finn Hill Middle School (2*/18) – Inglewood Middle School (1*/0) – Juanita High (2*/39) – Kamiakin Middle School (2*/12) – Keller (2*/7) – Kirkland Middle School (1*/8) – Lakeview Elementary (2*/2) – Lake Washington High School (1*/7) – Mead (2*/7) – Northstar Middle School (12) – Redmond High School (1*/10) – Redmond Middle School (1*/19) – Rush (2*/8) – Thoreau (2*/6)
None
Northshore
YELLOW
– Bothell High School (3*/12) – Canyon Creek Elementary (5**/11) – Canyon Park Middle School (1*/4) – Crystal Springs Elementary (1*/17) – Fernwood Elementary (1*/0) – Frank Love Elementary (1*/10) – Kenmore Elementary (1*/6) – Kenmore Middle School (4*/32) – Kokanee Elementary (0/1) – Leota Middle School (1*/2) – Maywood Hills Elementary (3*/4) – Moorlands Elementary (1*/2) – Northshore Middle School (1*/13) – Ruby Bridges Elementary (0/1) – Shelton View Elementary (0/2) – Skyview Middle School (1*/4) – Sunrise Elementary (2*/2) – Timbercrest Middle School (2*/0) – Wellington Elementary (1*/1) – Woodin Elementary (0/2) Woodmore Elementary (0/4)
None
Local Districts Scorecard – * indicates positive cases only ** indicates 5 or more confirmed positive cases – (x*/y) x is positive cases and 7 quarantined, quarantined does not include positive cases
We redefined the school district statuses. Information for classroom and building closures has been a challenge to obtain, both for closures and reopening. We are adopting moving any school with more than ten active COVID cases reported into the red, and we’ve adjusted the third column to reflect this change.
Based on reader feedback, and improvement in the data we are receiving, we have adjusted how we are reporting data. The Lake Washington and Northshore School Districts are now reported as (X*/Y) or (X**/Y). X represents the number of positive cases while Y represents how many are in quarantine. The number in quarantine does not include positive cases. If there are two asterisks, that indicates five or more confirmed cases within the last 14 days at that school.
Confirmed COVID cases were down in the three school districts we track. The Bellevue School District did not have updated data for quarantined students today.
The Lake Washington School District updates data once a week, and we’ve had no parent confirmed reports on new COVID cases this week.
We continued to encourage parents to request daily updates from the Lake Washington School District. This change would bring the three school districts we track into alignment.
Bellevue-Bothell-Kirkland-Woodinville local COVID news
King County Public Health updated the vaccination rates by zip code and now reports the data from ages 5 and up. Vaccination rates for children between 5 to 11 remain remarkable for the region.
Percentage of King County Residents 5 and older who have received at least one dose of COVID vaccine, December 2, 2021
Zip Code
Percent vaccinated, at least one dose, 5 to 11 years old
Percent vaccinated, at least one dose, 5 and older
98155
46.8%
92.5%
98028
42.7%
88.5%
98011
37.2%
85.2%
98034
38.8%
84.3%
98033
59.5%
93.5%
98072
39.2%
88.2%
98077
35.7%
80.2%
98052
55.0%
94.6%
98004
51.3%
>95.0%
98039
44.6%
90.7%
98005
53.4%
94.8%
98007
32.3%
88.0%
98008
44.5%
91.2%
98053
46.0%
92.9%
98074
50.5%
>95.0%
98075
43.0%
>95.0%
Vaccination rates with at least one dose
National Round-Up
Johns Hopkins University Cumulative Case Tracker reports 137,602 new cases and 1,960 deaths nationwide on Thursday. New cases continue to grow at a significant rate in the United States. There is no way to know if Omicron is driving the increase, but current data indicates that over 99% of new cases are Delta or one of its sublineages.
At least 10 Omicron COVID variant cases confirmed in the United States
Health officials in California, Colorado, Hawaii, Minnesota, and New York confirmed at least one case of the Omicron variant in their states.
Yesterday, the Centers for Disease Control confirmed the first Omicron variant case in the United States. The travel-related case was an 18 to 49-year-old male tested in the San Francisco area. They were fully vaccinated with an mRNA vaccine but not eligible for a booster because six months hadn’t passed since their second shot. They returned from South Africa on November 22 and tested on November 29. They have mild symptoms and are quarantined at home.
Late tonight, California officials reported a second travel-related case in Los Angeles county. That person traveled from South Africa to Los Angeles via London and returned on November 22. They are fully vaccinated but did not receive a booster. They are experiencing mild symptoms and are quarantined at home. Health officials reported they have already contacted and tested all close contacts, and didn’t find any new cases.
This morning Minnesota officials reported a community transmission case. The person identified as male, traveled to New York City to attend an anime convention at the Javits Center from November 19 to 21. The event had 53,000 attendees. They were fully vaccinated with an mRNA vaccine and had received a booster in early November.
Around lunchtime, Colorado officials reported a travel-related case. The woman was fully vaccinated but had not received a booster. She told authorities she had worn a mask during all her travels and developed symptoms after returning home from southern Africa last week. She has mild symptoms and is quarantined at home.
In the late afternoon, New York Governor Kathy Hochul reported five cases in the metro New York City area. There wasn’t little information available on each case, which is a combination of community transmission and travel-related. Two were in Queens, two in Brooklyn, one in Suffolk County, and one was not identified. The condition and vaccination status weren’t readily available.
Close to press time, officials in Hawaii reported their first case of an unvaccinated individual. The person had not traveled so officials believe it was caused by community transmission. The person is unvaccinated and was previously infected with COVID. They were tested on November 29, and currently are experiencing moderate symptoms. The press release from the State of Hawaii Department of Health did not indicate if they were hospitalized.
President Joe Biden announces winter battle plan to fight COVID
Under the threat of letting the United States default on its national debt, President Joe Biden conceded he would not push further vaccine mandates and announced other measures to combat COVID and the Omicron variant.
Requiring travelers entering the country by air to test negative for Covid-19 within a day of departure, regardless of vaccination status or nationality
Extending the requirement that masks be worn on airplanes, trains and public transportation to March 18
Requiring private health insurance companies to cover 100% of the cost of at-home tests for COVID
Public education to encourage 100 million eligible adults to get boosters shots
Editor’s Note: Consider us very underwhelmed.
Global update
New Omicron variant cases and hospitalizations skyrocket in South Africa
The number of new COVID cases and hospitalizations in South Africa is increasing at an alarming rate, with officials concerned that a record peak in infections is only 14 to 21 days away.
The South Africa Department of Health (SADOH) reported 74% of all detected COVID cases in November and 90% of new cases in the last week of the month were the Omicron variant. New cases have increased exponentially since November 24, the same day South African officials alerted the World Health Organization of the new variant.
Officials haven’t provided specifics on how much more transmissible Omicron is to previous variants, only saying that is higher.
New COVID cases in South Africa November 11 to December 2, 2021
SADOH reported 11,535 new cases today, an increase of 468% from a week ago. The 7 day rolling average for new cases jumped to 5,093. South Africa is testing about 52,000 people a day as the positivity rate increase at a significant rate. Officials reported 22.4% of the tests performed on Wednesday as positive for COVID infection.
In Gauteng Province, home to 15.7 million people, the number of hospitalized patients increased 23.4% overnight, jumping from 1,035 to 1,351 total patients. ICU patients increased by 38.5% while people needing oxygen held steady at 15% and ventilator use increased from 27 to 30.
Study from South Africa indicates COVID reinfection risk is very high
Researchers look at data from 2.8 million individuals who had lab-confirmed COVID positive tests at least 90 days before November 27, 2021. Among that group, they identified 35,670 lab-confirmed reinfections. The study found that reinfection with the Beta or Delta variant was infrequent, with disease acquired immunity providing protection. The research did not take the severity of illness into consideration for the initial or subsequent infections.
Reinfection rates from November 1 to November 27 increased by 240%, indicating that natural immunity may not provide much benefit. The results of the study could have implications on the effectiveness of monoclonal antibodies, but more data is required.
The study was done by a number of respected individuals but has not been peer-reviewed.
Disinformation
Although some officials have stated that Omicron cases appear to be mild, disinformation campaigns have latched on to these statements and are claiming an infection is no worse than a cold or flu.
On November 26 and again on November 28, Dr. Angleique Coetzee said that the infections she saw in her private practice were ‘very mild.’ On November 28 she expanded her statement to say that the observation was ‘not anecdotally’ and other clinicians were echoing her findings. She also stated that hospitalizations were not increasing. Her comments were addressed in a World Health Organization Omicron update on the same day.
“There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants. Initial reported infections were among university students—younger individuals who tend to have more mild disease—but understanding the level of severity of the Omicron variant will take days to several weeks.”
We do not believe that Dr. Coetzee is actively spreading disinformation and is speaking from her direct experience as a clinician. We also believe that people are misunderstanding what a ‘mild’ case of COVID means. A mild case is a case that doesn’t require clinical intervention or hospitalizations. With Covid-19 that’s more than a cold or the flu.
Dr. Rudo Mathivha is the head of critical care at Baragwanath Hospital in Soweto, a level 1 trauma center and the largest hospital in the Southern Hemisphere with 3,400 beds. Dr. Mathivha did a series of interviews in South Africa yesterday and reported she was seeing an increase in hospital admissions in children under 5 years old accompanied by a dramatic increase in patients needing high care and admission to the ICU.
“The number of ill patients presenting to hospitals has increased exponentially,” she said.
“We are seeing definitely a change in the demographic profile of patients. We are seeing toddlers under five presenting with symptoms and they are sick enough to require admission and to require supplemental oxygen.”
Researchers don’t know how severe Omicron infections will be at this time, and anyone making claims on the severity, either way, is not presenting informed information. Anyone claiming that Omicron is just a cold is spreading disinformation.
Knowledge is the best tool to fight against fear. A wise person chooses to be informed so they can make sound decisions. To join the fight against COVID misinformation, you can share this update through your social media platform of choice.
[KIRKLAND, Wash.] – (MTN) Health officials and researchers are in a race against time to unlock the secrets of the Omicron COVID variant and its potential impact on public health as more nations report discovered cases.
Washington state is one of the leaders in genomic sequencing of COVID tests samples in the United States, led by the University of Washington Medicine. Standard PCR tests can detect a marker for a potential Omicron variant. Omicron shares a mutation with the Alpha variant that the current PCR tests look for, enabling researchers to see if a specific spike protein has a deletion. That would become a probable case that would be tagged for confirmational sequencing.
President Joe Biden addressed the nation on Monday saying, “there are three messages about the new variant that I want the American people to hear. First, this variant is a cause for concern, not a cause for panic.”
The President went on to praise South African officials and their scientific community for, “the kind of transparency that should be encouraged and applauded.”
Currently, in Washington, 99.6% of new COVID cases are the Delta variant, and 0.4% are Mu. The last cases of the Beta, Epsilon, Eta, and Kappa variants were detected in June and the last cases of Gamma and Iota were in August.
“Omicron has an unprecedented number of spike mutations, some of which are concerning for their potential impact on the trajectory of the pandemic,” the WHO said in a statement today.
“The overall global risk related to the new variant …is assessed as very high.”
On Sunday, Dr. Angelique Coetzee told South Africa Today, “Most of these cases are mild whether they are vaccinated or not. There is no increase in our hospital admissions currently.”
Hospital admission for COVID-19 by week, South Africa Gauteng Province, Public and Private Hopsital, through November 28, 2021
Less than 12 hours later, the hospital admission data from the South Africa Department of Health painted a very different picture. In the previous week, COVID hospitalizations had increased 66% nationwide and 210% in Gauteng Province, the epicenter for Omicron cases. Two weeks ago 135 Covid-19 patients were hospitalized in and around Johannesburg jumping to 580 on Monday morning. Hospitalizations at public and private hospitals increased almost equally and officials at Baragwanath Hospital reported moderate to severe symptoms with almost all patients unvaccinated or partially vaccinated with the Pfizer vaccine.
Dr. Coetzee in her interview on Sunday went on to take a more cautionary position, “Two weeks from now we might say something different, but we urge…people out there please get vaccinated, listen, do the right thing, and stop going to big gatherings.”
She also added the unvaccinated should be worried, saying, “especially if you are above the age of 50, we have seen this many times.”
“There is a saying. You’re not safe until everyone is vaccinated.”
The 7 day rolling average for new COVID cases in South Africa grew to 2,275 on Monday, 90% of new cases are Omicron, and 10.8% of tests are coming back positive
The WHO appeared to address the reports from Dr. Coutzee and her reports on the severity of the new variant in a statement last night. “There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants.”
The statement added, “Initial reported infections were among university students—younger individuals who tend to have more mild disease—but understanding the level of severity of the Omicron variant will take days to several weeks.”
Dr. Coetzee saw her first suspected Omicron variant patient on November 18 and has based her statement of symptoms being mild on two-dozen patients who are mostly university students and younger, and about 50% vaccinated. In an interview with the BBC on Thursday, she stated all were in good health with no comorbidities.
Although she is credited and has self-proclaimed to have “discovered” Omicron, the first detection of the B.1.1.529 variant was collected on November 9 in Botswana and confirmed by South African scientists on November 11. South African officials notified WHO on November 24, a day before Dr. Coutzee stated she contacted South African authorities on her observations.
Despite a lot of unanswered questions, a clearer picture is slowly starting to emerge. The three riddles scientists need to solve are how contagious Omicron is compared to the Delta variant, can it escape public health measures, preventions, and treatments, and if the symptoms are the same, worse, or milder than previous variants.
Here is what is currently known about the Omicron COVID variant.
Symptoms
For children, adolescents, and young adults there is conflicting information. One doctor is reporting mostly mild symptoms that can be treated at home while hospital officials are reporting cases are similar to Delta.
The WHO stated on Sunday, “There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants.”
Transmissiblity
Concern is growing among the CDC, WHO, and a constellation of health officials that Omicron is highly transmissible. At least equal to Delta and possibly higher.
In less than two weeks, Omicron went from almost non-existent to 90% of new cases in South Africa. It appears it can effectively outcompete the Delta variant. However, this introduces bias in the data because the Delta wave had just ended in South Africa. Did Omicron become the dominant strain by outcompeting Delta or due to the absence of Delta? More research needs to be done to answer that question.
There are other variables that could explain the sharp increase in cases that go beyond the simple reproductive number, known as R0. Omicron has so many more mutations than previous strains, it could be benefiting from immune escape. Although the R0 is lower than Delta, its uniqueness compared to previous mutations enables it to reinfect people relying on natural immunity. So overall transmissibility may be lower than Delta, but its ability to escape immunity results in more infections.
Is it in the United States
Cassie Sauer, CEO of the Washington State Hospital Association said on Monday, “I think that there is almost no chance that it’s not [here.]”
The United States does not have a national standard or requirement to genetically sequence some or all COVID tests that come back positive. Those decisions are left up to individual states. It is likely that states with aggressive public health programs such as California, Washington, Colorado, New York, or Massachusetts will identify the first cases.
How long do researchers think Omicron has been circulating
Dr. Trevor Bedford from Fred Hutchinson in Houston, Texas successfully estimated the arrival of the original COVID strain in 2020, using data from the Washington State Department of Health. Using the same methodology, Dr. Bedford’s model indicates that Omicron likely started circulating between September 19 and October 21. There is no evidence to support that the variant originated in South Africa.
Credit – Dr. Trevor Bedford, Fred Hutchinson, Houston, Texas – probability of origin date for Omicron variant
Why are so many travelers testing positive
In total numbers, there aren’t many travelers testing positive. When you consider that in all but two cases the testing of 200 to 250 people on an aircraft has yielded one or two positives, the percentage of breakthrough cases is small. Headlines are blaring two positive cases detected, which is critical to know – they aren’t blaring 248 negative tests on 777 that landed tonight.
Because the people tested are 95% to 100% vaccinated, this creates a false data fallacy. You have an almost exclusive sample of vaccinated people.
In South Africa, the Department of Health has reported almost everyone hospitalized in the last two weeks is unvaccinated or only partially vaccinated. Dr. Coetzee reported 12 of 24 patients she cared for were unvaccinated.
Based on this early data, it appears the current vaccines remain at least moderately effective at preventing infection and remain very effective at stopping moderate to severe COVID.
Are the current vaccines ineffective
There isn’t enough data, and almost every public company making a vaccine announced over the weekend they were testing their current versions against Omicron. Pfizer, Moderna, and Johnson & Johnson announced over the holiday weekend they were testing to see if the current vaccines remained effective.
There is some data out of South Africa that is indicating that vaccines are helping prevent moderate to severe illness and the cases being detected among vaccinated travelers appear to be asymptomatic to mild. However, many of those cases were detected in the last 72 hours and more time is needed to see how these new cases will progress.
In Israel, the first three travel-related cases were fully vaccinated with boosters. One was Pfizer, one was J&J, and one was AstraZeneca. We know that the viral-vector vaccines haven’t performed as well against the Delta variant as the mRNA vaccines.
The evidence suggests that there is more vaccine escape with Omicron, but not outright vaccine ineffectiveness. It still appears to be preventing hospitalizations, which would indicate it would prevent deaths.
Pfizer said they could make a new version if required in 100 days and Moderna said it would take 60 to 90 days. Johnson & Johnson did not provide a timeline but made a statement today they could create an updated version if it was required.
There are some new COVID vaccines in development called subunit vaccinations. There has been no information about the impact Omicron will have on the research.
Is disease acquired immunity still effective
There is growing evidence that immunity gained from a previous COVID infection that isn’t supported by vaccination, is experiencing significant breakthrough numbers.
Researchers are working to determine if the sharp increase in the number of cases and the high positivity rate of tests is due to Omicron being equally or more transmissible than Delta, or if part of the increase is being driven by other factors.
The pattern of mutations found in Omicron is very distant from all previous strains.
Are monoclonal antibodies still effective
There is evidence that Omicron has a significant ability to resist monoclonal antibodies. Specific mutations may have the capability to not only bypass B cells but resist T cells (which isn’t the same as HIV which destroys your T cells).
UW Medicine is evaluating the performance of currently available antiviral treatments and we will know more information in the coming weeks.
Will the new antivirals that are pending approval still be effective
There was a report from Pfizer on Monday morning that Paxlovid is effective against the Omicron variant, which is very good news. This is easy to administer than monoclonal antibodies, easier to distribute, and cheaper.
Nothing has been stated about Monulpiravir from Merck. The FDA will be considering the EUA request this week but there are hints they will label Monulpiravir a Class C drug if the EUA is granted. A Class C drug can’t be used by pregnant women, women actively trying to get pregnant, and nursing mothers because the drug has not been tested to determine if it causes birth defects or pregnancy complications. The FDA has already requested data for Merck to understand the impact better.
What should I do
Health officials recommend you continue to do the same things you are doing now. Get vaccinated if you’re not already. Get a booster shot if you’re eligible, and over 2.4 million Washingtonians are currently eligible. Wear a mask, wash your hands, avoid crowded indoor spaces, and reconsider your short term travel plans if you were planning to fly.
[KIRKLAND, Wash.] – (MTN) Public health officials are scrambling to understand the seriousness of the Omicron Covid-19 variant as a growing list of nations report probable and confirmed cases.
First confirmed on November 11 among four people from Botswana who had returned from traveling to neighboring South Africa, new cases in the nation of 59 million have leaped from 356 on the 11th to 3,220 on Saturday. Test positivity also increased dramatically in the last 16 days climbing from 1.1% to 9.2%. Test positivity over 5% is an indicator of under testing and over 7% is a signal there is growing community transmission.
Confirmed COVID cases in South Africa from November 11 to November 27, Data from South Africa Ministry of Health COVID Daily Report Dashboard
On Friday, the World Health Organization (WHO) named the variant formerly known at B.1.1.529, Omicron, and labeled it a Variant of Concern (VOC). The variant has more than 50 mutations from the original COVID strain and shares many mutations with other VOCs. There are 32 mutations on the spike proteins, which can potentially impact transmissibility and increase the level of vaccine escape the Delta variant has.
Before the WHO met on Friday, new cases were confirmed in Israel, Belgium, and Hong Kong. By Saturday, Italy, England, Germany, and the Czech Republic have reported confirmed cases. Netherlands officials stopped two flights arriving from Johannesburg and retested more than 650 people for Covid-19, finding 61 new cases. The people who tested positive have been placed in isolation and their cases are being genetically sequenced to determine which variant they have.
On Friday evening all but two confirmed cases of the Omicron variant outside of the African continent were travel-related. One case in Belgium appears to have been caused by community spread. In Hong Kong, a person in a quarantine hotel became infected by another COVID positive occupant “across the hall.” The case detected in Belgium involves an unvaccinated individual while the Hong Kong case involves a person vaccinated in May or June.
Disinformation is spreading that cases are only among the vaccinated. South Africa had some early success in rolling out the COVID vaccine, but today only 24.11% of the population is fully vaccinated. Further misinformation that vaccines created the mutation isn’t supported or factual. Vaccines prevent mutations by reducing the number of people who can be infected and only 6% of all Africans are vaccinated against COVID. Because most recreational international travel requires a person to be fully vaccinated, travel-related cases are creating a short-term data fallacy.
Many nations including the United States and Canada have announced travel restrictions or bans to a varying list of six to ten countries in the southern part of Africa. Starting Sunday, air travel from South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique, and Malawi will be restricted to US citizens and lawfully permanent residents. Delta and United Airlines have direct flights to South Africa from the United States.
A chorus of epidemiologists and health officials are calling the restrictions ineffective and politically motivated.
Based on the history of other variants it is likely Omicron was circulating before its November 9 detection. The United States relaxed air travel restrictions on November 8. There are no confirmed or suspected cases in North America, but infectious disease expert Dr. Anthony Fauci told reporters it is “possibly” already here.
One mutation is working in favor of public health and helping track the spread of the new variant. Omicron is missing a protein, and the absence can be detected by a PCR test. Genomic sequencing is still required for final confirmation, but the mutation makes probable cases easy to detect.
Pfizer and its Germany partner BioNTech as well as Moderna announced on Friday there were studying the efficacy of the currently available COVID vaccines and have plans to create an update if required. Both indicated research would take approximately two weeks and Pfizer stated a new vaccine could be available in 100 days, pending regulatory approval.
“From the beginning, we have said that as we seek to defeat the pandemic, it is imperative that we are proactive as the virus evolves,” said Moderna’s Chief Executive Officer Stéphane Bancel. “We have three lines of defense that we are advancing in parallel: we have already evaluated a higher dose booster of mRNA-1273, second, we are already studying two multi-valent booster candidates in the clinic that were designed to anticipate mutations such as those that have emerged in the Omicron variant and data is expected in the coming weeks, and third, we are rapidly advancing an Omicron-specific booster candidate.”
Doctors at UW Medicine in Seattle are studying the effectiveness of antiviral medications against the new strain. Dr. Deborah Fuller, speaking with local TV station KCPQ, did not specifically state if monoclonal antibodies such as Regeneron, molnupiravir by Merck, or Paxlovid by Pfizer were being studied.
Regeneron has been an effective early treatment for COVID and is credited with preventing as many as 10,000 hospitalizations in Florida. Some of the mutations indicate that Omicron may be able to resist or escape the drug. Molnupiravir is an antiviral developed in 2019 as a treatment for Influenza, Ebola, and other viral infections. Research showed the oral medication halved severe Covid-19 infections and deaths and is pending Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA). Paxlovid was developed as a therapeutic for Covid-19 and was 89% effective at preventing hospitalization. The antiviral is also an oral medication and is being reviewed by the FDA to receive a EUA.
Molnupiravir is an antiviral medication currently under evaluation by the FDA that has shown strong promise as a viable COVID treatment
New York Governor Kathy Hochul declared a state of emergency on Friday evening ahead of any new case spikes. The declaration goes into effect on December 3 and will enable the state to increase hospital capacity and release funds to hire additional staff and medical supplies. When the United States State Department eased travel restrictions on November 8, New York City was the number one chosen destination for European travelers. Orlando and Phoenix were number two and three.
A lot more will be known in the next two to four weeks about Omicron. The three questions epidemiologists will be working to answer include does Omicron spread faster than Delta, can Omicron escape some of our therapies and public health measures, and if those sickened by the new variant suffer from equal, more severe, or more mild symptoms.
Public health officials recommend that getting vaccinated and getting your booster if you’re eligible, wearing masks, avoiding crowded indoor spaces, and deferring travel are the best lines of defense until more is known. People who feel sick should not dismiss their symptoms as a cold or flu and should test for COVID. A positive result with a home test should be followed up with a PCR test to confirm the results and help public health track which variants are spreading.
The Washington State Department of Health is closed from Thursday to Sunday for the Thanksgiving holiday and has not made any statement.
As of Saturday afternoon, the number of confirmed cases globally can be counted in the dozens – caution and not panic should be the word of the day.
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